Fig. 2
From: Shared etiology of Mendelian and complex disease supports drug discovery
Clinical associations between Mendelian and complex diseases predict candidate drugs with higher potential of success for the complex diseases. (A) Odds ratio of candidate drugs to be currently investigated or indicated for the complex diseases within a disease category. Only disease categories that are significant compared to 1,000 permutations of the comorbidity relationships (ppermutation<0.05) are shown. (B) Examples of recommended candidate drugs for 14 neoplasms based on their clinical associations with 2 Mendelian diseases: Androgen Insensitivity Syndrome and Retinitis Pigmentosa. Gray-scaled boxes indicate the phase of the drug in the development pipeline for each neoplasm. (C) Odds ratio of candidate drugs to be investigated or indicated for a complex disease per drug development phase. * in A and C, bars represent the observed odds ratio with 95% confidence intervals