Fig. 1
From: Shared etiology of Mendelian and complex disease supports drug discovery
Outline of the approach. A. Proposed method where the drugs targeting genes causally associated with a Mendelian disease are suggested as candidate drugs for its clinically associated (comorbid) complex disease. This hypothesized connection between the drug and the complex disease is based on the previously shown pleiotropic effects of the Mendelian disease causal genes on the development of the comorbid complex disease. B. Distribution of the number of comorbid complex diseases per Mendelian disease. C. Number of investigated (per clinical trial phase) and approved drugs for each complex disease