Fig. 1

Pedigree of the family and abnormalities of the fetus detected by prenatal ultrasound. A Pedigree of the family: members affected by KOS are colored in black and the member affected by TS is colored in dark gray. ECT, ectopic pregnancy; SB, still birth. B Ultrasound image showing clenched hands with overlapping fingers and polyhydramnios with a deepest vertical pocket of 12.98 cm. B Fetal growth trajectories of head circumference, abdominal circumference and estimated fetal weight, NICHD Fetal Growth Studies—Singletons