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Fig. 3 | BMC Medical Genomics

Fig. 3

From: Major depletion of insulin sensitivity-associated taxa in the gut microbiome of persons living with HIV controlled by antiretroviral drugs

Fig. 3

Gut Microbiome Modules (GMMs) with significant differences across study groups. (A) Heatmap of Cliff’s Delta effect sizes (right panel) of 77 GMMs with significant differences in abundance between PWH individuals (n = 25) and MetaCardis (n = 25), MetaHit (n = 25) and MicroObes (n = 25) individuals (#=FDR < 0.05; *=p-value < 0.05; Wilcoxon rank-sum test). Positive values correspond to GMMs significantly increased in PWH, whereas negative values correspond to GMMs significantly depleted in PWH. Left panel represents the robustness of the associations to MSM status (FDR < 0.1; Wilcoxon rank-sum test in MSM vs. control and no-MSM vs. control comparisons; n = 13 MSM, n = 10 no-MSM) (B-C) Boxplots of GMMs abundances across study groups for Butyrate production modules (significant decrease in PWH individuals vs. all three control groups and robust to MSM status; highlighted in green in panel A)

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BMC Medical Genomics

ISSN: 1755-8794

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