Fig. 3

Synpolydactyly-associated polyalanine expansions alter the immune response and osteoclast differentiation. A Gene significance across modules for myoblasts from spdh and WT scRNA-seq data. B Module membership in the turquoise module and gene significance for myoblasts from spdh and WT scRNA-seq data. C Expression of four differential genes of myoblasts in each module from spdh and WT scRNA-seq data. D Treemap of the top 10 condensed gene ontology (GO) terms for the turquoise module from spdh and WT scRNA-seq data, with box size corresponding to the number of significant terms associated with the GO category. E Representative KEGG pathways of the turquoise module from spdh and WT scRNA-seq data. ‘‘Count’’ stands for gene number. The color keys from yellow to blue indicate the range of the p value