FLT4 gene polymorphisms influence isolated ventricular septal defect predisposition in a Southwest China population

Table 2 Comparison of the gene frequency of 10 SNPs in the VSD population and normal population

Gene	SNP	Minor/Major	MAF (VSD)	MAF (control)	Alle	HWE-P
		Minor/Major			P value
FN1	rs6707530	T/G	0.21	0.26	0.060	0.249
DNAH5	rs12659700	T/C	0.11	0.13	0.271	0.742
FLT4	rs383985	(C + T)/G	0.19	0.24	0.040	0.444
LAMC3	rs710074	C/A	0.35	0.36	0.515	0.730
COL5A1	rs3124309	T/C	0.50	0.49	0.778	0.872
COL4A1	rs598893	C/T	0.20	0.21	0.812	0.310
IQGAP1	rs2589941	C/T	0.17	0.15	0.342	0.305
HYDIN	rs1774266	A/G	0.43	0.42	0.686	0.265
	rs7198975	A/G	0.43	0.42	0.726	0.237
B9D1	rs11650112	T/C	0.17	0.13	0.087	0.103

P value in boldface indicates statistical significance (P < 0.05), SNP, single nucleotide polymorphism; MAF(VSD), Minor allele frequency in VSD patients; MAF (control), Minor allele frequency in normal controls; HWE-P, P value of Hardy–Weinberg equilibrium

ISSN: 1755-8794