Fig. 1

Haplotype structure of FLT4 and genomic position of FLT4. (A) Greyscale indication: black represents D ’ = 1; white represents D ’ = 0; 0 < D ’ < 1, the darker the colour, the bigger D ’ is. r² values times 100 are shown in the square. The red circle marks the location of FLT4 rs383985, and the red arrow marks the strong linkage r² value and corresponding site location. (B) The positions of the high linkage disequilibrium SNPs annotated using the NCBI dbSNP database and lollipop labels show that FLT4 rs3736061, rs383985, rs3736062 and rs3736063 were discovered in the GRCh37 assembly. (C) Protein polymorphism map. Lollipop labels show that FLT4 rs3736061 and rs3736062 SNPs, which cause a synonymous change in the amino acid, were located at 169 and 448