A novel splice-altering TNC variant (c.5247A > T, p.Gly1749Gly) in an Chinese family with autosomal dominant non-syndromic hearing loss

Table 1 Clinical characteristics of patients with TNC variants in this study

Family members	III:3	III:5	IV:5	IV:7	IV:8
Sex	Female	Male	Female	Male	Female
Age	52	48	28	23	15
Age of onset (years)	16	10	12	6	6
Severity of hearing loss	Severe	Severe	Moderately severe	Moderately severe	Moderately severe
Verbal expression	Normal	Normal	Normal	Minor anomaly	Minor anomaly
Intelligence assessment	Normal	Normal	Normal	Normal	Normal
ABR	Normal	Normal	Normal	Normal	Normal
DPOAE	Absent at all frequencies	Absent at all frequencies	Absent at all frequencies	Absent at all frequencies	Absent at all frequencies
General physical examination	Normal	Normal	Normal	Normal	Normal
Vertigo (Yes or No)	No	No	No	No	No
Tinnitus (Yes or No)	No	No	No	No	No
Exposure to noise (No or Yes)	No	No	No	No	No
Ototoxic drugs expose (No or Yes)	No	No	No	No	No

ISSN: 1755-8794