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Table 5 Genotype and allele frequency distribution of rs104893674 polymorphism in ALL, AML and MPAL patients and controls

From: Genetic evidence for predisposition to acute leukemias due to a missense mutation (p.Ser518Arg) in ZAP70 kinase: a case-control study

Phenotype

SNP

Controls

n (%)

Patients

n (%)

OR (95% CI)

Uncorrected p

Corrected p

 

rs104893674

   

< 0.001

< 0.004

CC

37(37.4)

0(0)

1.09(0.66–0.97)

ALL

AC

64(62.6)

94(89)

1.57(1.37–1.85)

 

AA

0(0)

7 (11)

1

< 0.001

< 0.006

C

136(68)

94(50)

1.47(1.20–1.80)

A

62(32)

94(50)

2.19(1.44–3.32)

rs104893674

     

CC

14(9.9)

1(1.3)

1

0.027

0.031

AML

AC

79(84)

91(97.1)

0.6 (0.4–0.9)

 

AA

2(1.6)

6(6.1)

0.2(0.1–0.3)

C

95(47.5)

91(45.5)

1

0.068

0.074

A

105(52.5)

109(54.5)

0.9 (0.6–0.8)

 

rs104893674

     
 

CC

14(60.8)

2(15.4)

0.55(0.2–0.8)

  

MPAL

AC

6(26.1)

9(57.7)

0.84(0.4–1.2)

< 0.001

< 0.003

 

AA

3(13.1)

4(26.9)

0.46(0.15–0.3)

 

C

28(69.4)

4(3.8)

0.78(0.3–1.1)

< 0.001

< 0.002

 

A

18(30.6)

26(96.2)

0.99(0.4–3.1)

  1. Note: Corrected p-values were calculated by using Bonferroni’s correction