Fig. 3

CNV analyses and SNP-based haplotype analyses results of the family members and embryos of HLA. A CNV analyses results of the embryos. B The SNP-based haplotype linkage analyses of HLA. All the embryos were identified with chromosomal normality except embryo E1 which is mosaic partial trisomy (chr) 16. And there were 3 embryos HLA-matched with the proband. The dark blue and the dark orange bars represent the proband-HLA-unmatched haplotype of the father and the mother, respectively. The slashes filled orange bar denotes the proband-HLA-matched haplotype of the mother, and the backslashes filled light blue bar denotes the proband-HLA-matched haplotype of the father. Color keys of the upstream and downstream informative SNPs of the five HLA gene regions (HLA-A, HLA-B, HLA-C, HLA-DR and HLA-DQ) were showed in the figure legend on the right. A 0/0 in the haplotype means unsuccessful genotyping for the marker in that sample