Table 4 Enrichment of cancer-specific somatic driver genes for multi-tissue networks applied to cancer GWAS summary statistics
Matched tissue-specific network | p-value | Multi-tissue network | p-value |
|---|---|---|---|
breast cancer | 8.28 × 10− 5 | multi-tissue cancer | 3.51 × 10− 4 |
breast non-cancer | 2.23 × 10− 15 | multi-tissue non-cancer | 2.94 × 10− 6 |
colon cancer | 3.44 × 10− 6 | multi-tissue cancer | 0.008 |
colon non-cancer | 2.98 × 10− 8 | multi-tissue non-cancer | 8.43 × 10− 4 |
prostate cancer | 5.40 × 10− 4 | multi-tissue cancer | 1.27 × 10− 6 |
prostate non-cancer | 3.29 × 10− 4 | multi-tissue non-cancer | 0.049 |
skin cancer | 0.125 | multi-tissue cancer | 0.175 |
skin non-cancer | 0.238 | multi-tissue non-cancer | 1.00 |