Fig. 3

Enrichment of cancer-specific somatic driver genes for all combinations of different multi-tissue and tissue-specific gene-prioritisation methods applied to cancer GWAS summary statistics. X-axis indicates the different tissue networks created based on cancer tissue data from TCGA and the different non-cancer tissue networks created based on tissue data from recount3. Y-axis indicates the different GWAS considered in our study. A one-sided Wilcoxon rank-sum test was used to calculate the enrichment of cancer-specific somatic driver genes in the list of prioritised genes. Rectangles with a black border correspond to the tissue-specific gene-prioritisation method that matches the tissue of origin for the cancer GWAS trait. The violin chart on the right highlights an example comparison for the breast cancer GWAS results in the non-cancer adipose-breast network