Molecular genomic and epigenomic characteristics related to aspirin and clopidogrel resistance

BMC Medical Genomics

Table 3 Hierarchical linear regression analysis to predict ARU level

Variable groups and model performance		Model 1				Model 2
Variable groups and model performance		B	β	t value	VIF	B	β	t value	VIF
	Constant	509.475		20.138***		496.985		7.431***
Blood tests	Platelet	-0.084	-0.087	-2.470*	1.247	-0.072	-0.075	-2.086**	1.305
Mediators	LTB4					-0.008	-0.089	-2.604**	1.191
Single nucleotide polymorphisms	COX2 (rs20417) C/G					-12.344	-0.067	-2.085*	1.041
Single nucleotide polymorphisms	TXA2R (rs1131882) A/A					-12.599	-0.107	-2.281*	2.249
Promoter methylation	COX1					2.73	0.086	2.471*	1.231
Promoter methylation	ALOX15					-1.672	-0.076	-2.369*	1.063
Model summary	r	0.163				0.291
	R²	0.027				0.084
	Adjusted R²	0.008				0.033
ANOVA	F value	1.396				1.626**

Model 1 = Regression analysis performed with variables including cardiovascular risk factors + blood tests
Model 2 = Regression analysis with variables including cardiovascular risk factors + blood tests + mediators + single nucleotide polymorphisms + promoter methylations
B Unstandardized coefficient, β Standardized coefficient, *p < 0.05; **p < 0.01; ***p < 0.001
Reference group to create dummy variables: COX2 (rs20417) = C/C; TXA2R (rs1131882) = G/G.
ANOVA Analysis of variance, VIF Variance inflation factor
ALOX15 15-lipoxygenase gene, COX1 Cyclooxygenase 1, COX2 Ccyclooxygenase 2 gene, LTB4 Leukotriene B4, TXA2R Thromboxane A2 receptor gene

ISSN: 1755-8794