Molecular genomic and epigenomic characteristics related to aspirin and clopidogrel resistance

BMC Medical Genomics

Table 2 Hierarchical logistic regression analysis to predict clinical resistance

Variable groups and model performance	Variables	Model 1		Model 2
Variable groups and model performance	Variables	B	Exp(B)	B	Exp(B)
Constant		-9.833	0.000***	-13.085	0.000***
Risk factors/blood tests	Smoking (Yes)	1.198	3.313**	1.214	3.368 **
	Triglyceride	-0.008	0.992*	-0.008	0.992 *
	Hemoglobin A1c	0.262	1.300*	0.271	1.311*
Single nucleotide polymorphisms	TXAS1 (rs41708) A/A			1.495	4.459*
Promoter methylation	ALOX12			0.037	1.038*
Model performance†	Specificity	99.5		99.2
	Sensitivity	3.4		13.8
	Accuracy	96.7		96.7

†Classification threshold to test the model performance of each logistic regression model: 0.3
Model 1 = Regression analysis performed with variables including cardiovascular risk factors + blood tests
Model 2 = Regression analysis with variables including cardiovascular risk factors + blood tests + mediators + single nucleotide polymorphisms + promoter methylation
B Unstandardized coefficient, β Standardized coefficient, *p < 0.05; **p < 0.01; ***p < 0.001
Reference group for TXAS1 (rs41708) = C/C
ALOX12 12-lipoxygenase gene, TXAS1 Thromboxane synthase 1 gene

ISSN: 1755-8794