Table 5 Compounds with z score ≤-2.0 for both PSC and PSC with current use or under investigation
Drug | PSC z-score | PBC z-score | Current use | Under investigation for |
|---|---|---|---|---|
Denileukin diftitox | -5.087 | -3.975 | Cutaneous T-cell lymphoma | Â |
Basiliximab | -5.038 | -3.320 | Kidney transplant rejection prophylaxis | Â |
Abatacept | -3.787 | -4.603 | RA/psoriatic arthritis/GVHD prophylaxis | Â |
Belatacept | -3.733 | -4.709 | Kidney transplant rejection prophylaxis | Â |
NF-kappaB Decoy | -2.759 | -2.809 | Â | inflammatory disorders |
CYT997 | -2.731 | -2.593 | Â | solid tumours |
Galiximab | -2.714 | -4.217 | Â | lymphoma, psoriasis, RA |
P54 | -2.642 | -2.362 | Â | Cancers, IBD, OA |
Arotinoid acid | -2.637 | -4.419 | Â | psoriasis |
SGN-30 | -2.562 | -2.401 | Â | autoimmune disease, cancers |
NOX-700 | -2.560 | -2.461 | Â | T2DM |
Custirsen | -2.515 | -2.206 | Â | brain/breast cancers |
HE3286 | -2.474 | -2.163 | T2DM and RA | Â |
Thiocolchicoside | -2.470 | -4.217 | Â | rheumatological disorders, muscle contraction |
Fostamatinib | -2.412 | -3.305 | Chronic ITP | Â |
Denosumab | -2.321 | -4.416 | Osteoporosis | Â |
AMGN-0007 | -2.255 | -4.203 | Â | osteoporosis/bone metastases |
Andrographolide | -2.113 | -2.592 | Â | UC |
Tucatinib | -2.013 | -2.821 | Breast cancer | Â |
Pazopanib | -2.011 | -2.462 | Renal cell, soft tissue, thyroid cancer | Â |