Analysis of human papillomavirus type 16 E4, E5 and L2 gene variations among women with cervical infection in Xinjiang, China

Table 6 Genetic variation of genomic HPV16 E5 in case and control groups

	Variation sites	Control groups		Case groups		P values	Amino acid changes
	Variation sites	Number of variation samples(n = 47)	Variation frequency	Number of variation samples(n = 43)	Variation frequency	P values	Amino acid changes
Synonymous variation	A2991G	0	0.00%	1	2.33%	0.293	T2T
	A3018G	1	2.13%	0	0.00%	0.336	L11L
	G3153A	0	0.00%	1	2.33%	0.293	A56A
	A3207C	1	2.13%	0	0.00%	0.336	I74I
	A3213T^a	6	12.77%	14	32.56%	0.024	T76T^a
	A3228G	0	0.00%	1	2.33%	0.293	L81L
Nonsynonymous variation	C2995T	0	0.00%	2	4.65%	0.135	L4F
	T3031G	1	2.13%	0	0.00%	0.336	L16V
	T3068C	1	2.13%	0	0.00%	0.336	L28S
	A3115C	32	68.09%	36	83.72%	0.085	I44L
	T3122C	3	6.38%	1	2.33%	0.351	V46A
	C3127A	6	12.77%	4	9.30%	0.601	L48I
	C3127G	1	2.13%	3	6.98%	0.265	L48V
	A3178G	47	100.00%	43	100.00%	1	I65V
	T3179G	1	2.13%	0	0.00%	0.336	I65R
	A3180G	0	0.00%	1	2.33%	0.293	I65M
	T3226G	0	0.00%	1	2.33%	0.293	L81V

ISSN: 1755-8794