Analysis of human papillomavirus type 16 E4, E5 and L2 gene variations among women with cervical infection in Xinjiang, China

Table 5 Genetic variation of genomic HPV16 E4 in case and control groups

	Variation sites	Control groups		Case groups		P values	Amino acid changes
	Variation sites	Number of variation samples(n = 47)	Variation frequency	Number of variation samples(n = 43)	Variation frequency	P values	Amino acid changes
Synonymous variation	G2504A	1	2.13%	0	0.00%	0.336	K12K
	T2520C	13	27.66%	12	27.91%	0.979	L18L
	T2534G	0	0.00%	1	2.33%	0.293	T22T
	C2546T	40	85.11%	36	83.72%	0.856	T26T
	C2546A	1	2.13%	1	2.33%	0.949	T26T
	G2585A	11	23.40%	12	27.91%	0.625	P39P
	A2603G	0	0.00%	1	2.33%	0.293	L45L
	T2660C	9	19.15%	10	23.26%	0.633	C64C
Nonsynonymous variation	T2489G	0	0.00%	1	2.33%	0.293	C7 W
	G2496T	0	0.00%	1	2.33%	0.293	A10S
	A2506G	0	0.00%	1	2.33%	0.293	Y13C
	A2587C	0	0.00%	1	2.33%	0.293	K40T
	G2596T	0	0.00%	1	2.33%	0.293	R43I
	G2621T	0	0.00%	1	2.33%	0.293	Q51H
	G2627T	0	0.00%	1	2.33%	0.293	Q53H
	G2669C	1	2.13%	0	0.00%	0.336	E67D
	T2703G	0	0.00%	1	2.33%	0.293	L79V
	C2712T	0	0.00%	1	2.33%	0.293	H82Y
	C2716G	0	0.00%	1	2.33%	0.293	T83R

ISSN: 1755-8794