Table 4 HPV16 L2 gene variation and amino acid changes

Synonymous variation

A3459C

A

A

A

1

1.11%

P29P

T3528G

T

T

T

1

1.11%

G52G

A3531T

A

A

A

1

1.11%

V53V

T3534C

T

T

T

3

3.33%

F54F

T3540G

T

T

T

9

10.00%

G56G

C3573G

G

G

G

1

1.11%

G67G

A3594T

A

A

A

1

1.11%

P74P

A3594C

A

A

A

2

2.22%

P74P

A3627C

A

A

A

1

1.11%

T85T

G3699T

G

G

G

3

3.33%

V109V

T3726G

T

T

T

2

2.22%

G118G

A3735T

C

A

A

1

1.11%

T121T

T3852C

T

T

T

1

1.11%

N160N

C3861T

T

T

T

4

4.44%

F163F

G3879A

G

G

G

1

1.11%

L169L

A3891C

A

A

A

1

1.11%

T173T

A3897G

A

A

A

1

1.11%

A175A

A3906G

A

A

A

1

1.11%

G178G

T3912C

T

T

T

1

1.11%

H180H

A3924C

A

A

A

1

1.11%

S184S

A3972T

A

A

A

1

1.11%

T200T

C3984T

C

C

C

2

2.22%

S204S

G4074A

A

A

A

90

100%

Q234Q

T4083C

T

T

T

1

1.11%

V237V

T4119C

T

T

T

1

1.11%

L249L

G4144A

G

G

G

1

1.11%

E258E

T4275A

T

T

T

4

4.44%

I301I

T4320G

T

T

T

1

1.11%

G317G

A4362G

A

C

A

7

7.78%

L330L

A4437G

A

A

A

1

1.11%

A355A

A4464G

A

A

A

1

1.11%

G364G

T4494C

T

T

T

1

1.11%

I374I

A4518T

A

A

A

1

1.11%

V382V

A4602G

A

A

A

15

16.67%

L410L

C4623T

T

C

C

2

2.22%

P417P

T4626C

T

T

T

1

1.11%

I418I

A4653G

A

A

A

1

1.11%

L427L

Nonsynonymous variation

C3376G

C

C

C

1

1.11%

R2G

G3377A

G

G

G

7

7.78%

R2Q

C3389T

C

C

C

2

2.22%

S6F

A3396C

A

A

A

1

1.11%

K8N

G3398C

G

G

G

1

1.11%

R9P

C3416T

C

C

C

1

1.11%

A15V

C3424T

C

C

C

1

1.11%

L18F

G3481A

G

G

G

1

1.11%

E37K

G3554A

G

G

G

8

8.89%

G61E

G3578C

C

C

C

5

5.56%

R69P

A3580C

A

A

A

2

2.22%

T70P

A3589T

A

A

A

1

1.11%

I73F

G3599A

G

G

G

7

7.78%

G76E

G3622A

G

G

G

23

25.56%

D84N

G3641A

G

G

G

40

44.44%

R90K

T3656A

T

T

T

2

2.22%

V95E

G3658A

G

G

G

43

47.78%

D96N

T3665G

T

T

T

7

7.78%

V98G

G3688T

G

G

G

1

1.11%

V106F

T3698G

T

T

T

9

10.00%

V109G

G3700A

G

G

G

2

2.22%

E110K

G3703A

G

G

G

32

35.56%

E111K

G3710T

G

G

G

8

8.89%

S113I

A3715G

A

A

A

2

2.22%

I115V

G3757A

G

G

G

27

30.00%

D129N

A3862T

A

A

A

1

1.11%

T164S

A3881G

A

A

A

1

1.11%

Q170R

C3910T

C

C

C

1

1.11%

H180Y

C3919G

C

C

C

1

1.11%

L183V

G3952A

G

G

G

2

2.22%

E194K

G3955A

G

G

G

1

1.11%

E195K

A3958T

A

A

A

1

1.11%

I196F

A3976T

A

A

A

1

1.11%

I202F

G4061T

G

G

G

1

1.11%

R230L

C4072A

C

C

C

1

1.11%

Q234K

G4087T

G

G

G

1

1.11%

D239Y

G4099A

G

G

G

3

3.33%

V243I

G4129C

G

G

G

1

1.11%

D253H

T4177G

C

C

C

2

2.22%

S269A

T4177C

C

C

C

32

35.56%

S269P

C4178A

C

C

C

1

1.11%

S269Y

A4180G

A

A

A

2

2.22%

S270G

G4181A

G

A

G

3

3.33%

S270N

G4186A

G

G

G

5

5.56%

D272N

A4190G

A

A

A

1

1.11%

N273S

A4192C

A

A

A

1

1.11%

S274R

A4203G

A

A

A

1

1.11%

I277M

C4207A

C

C

C

1

1.11%

P279T

A4288C

A

A

A

1

1.11%

I306L

A4301G

A

A

A

1

1.11%

Q310R

A4318G

A

A

A

1

1.11%

S316G

G4322A

G

G

G

1

1.11%

G317E

T4327G

T

T

T

1

1.11%

S319A

A4339G

A

A

A

1

1.11%

K323E

A4362C

A

C

A

46

51.11%

L330F

A4362T

A

C

A

35

38.89%

L330F

C4367A

C

C

C

1

1.11%

T332N

G4372A

A

G

A

3

3.33%

D334N

A4385G

A

A

A

1

1.11%

E338G

G4390A

G

G

G

1

1.11%

E340K

A4405C

A

A

A

1

1.11%

T345P

T4441A

T

T

T

1

1.11%

S357T

A4460C

A

A

A

1

1.11%

N363T

C4505T

T

T

C

6

6.67%

S378F

A4628C

A

A

A

4

4.44%

N419T

A4630G

A

A

A

1

1.11%

I420V

A4654C

A

C

A

21

23.33%

I428L