Table 2 Mendelian randomization (MR) results where glucose, HbA1c and T2DM as the outcome and IBD as the exposure
Outcome | P | OR(95%CI) | P for Q-Test | P for Intercept |
|---|---|---|---|---|
Fasting glucose | ||||
IVW | 0.590 | 0.995(0.977–1.013) | 2.27*10− 6 | 0.868 |
MR Egger | 0.958 | 0.999(0.953–1.046) | ||
Simple mode | 0.628 | 0.994(0.972–1.016) | ||
Weighted median | 0.393 | 0.994(0.981–1.007) | ||
Weighted mode | 0.419 | 0.993(0.977–1.009) | ||
HbA1c | ||||
IVW | 0.203 | 1.052(0.973–1.137) | 5.96*10− 3 | 0.442 |
MR Egger | 0.248 | 1.132(0.931–1.376) | ||
Simple mode | 0.580 | 0.973(0.884–1.069) | ||
Weighted median | 0.592 | 1.019(0.950–1.093) | ||
Weighted mode | 0.887 | 1.006(0.932–1.084) | ||
T2DM | ||||
IVW | 0.964 | 0.998(0.917–1.085) | 6.20*10− 3 | 0.837 |
MR Egger | 0.851 | 1.035(0.733–1.461) | ||
Simple mode | 0.793 | 1.014(0.920–1.115) | ||
Weighted median | 0.688 | 1.014(0.948–1.082) | ||
Weighted mode | 0.664 | 1.019(0.940–1.103) |