Table 1 Genotype and allelic frequencies of two IL–6 promoter polymorphisms among SARS-CoV-2 cases and uninfected- controls and associations with risk of COVID-19

rs1800795

Codominant

 G/G

249 (73.5)

204 (75.5)

Reference

 G/C

80 (23.6)

58 (21.5)

0.94 [0.63–1.41]

0.95

 C/C

10 (2.9)

8 (3.0)

0.90 [0.34–2.41]

Recessive model, n (%)

 G/G + G/C

329 (97.0)

262 (97.0)

Reference

–

 C/C

10 (3.0)

8 (3.0)

0.91 [0.34–2.43]

0.85

Dominant model, n (%)

 G/G

249 (73.4)

204 (75.6)

Reference

–

 G/C + C/C

90 (26.6)

66 (24.4)

0.94 [0.64–1.38]

0.75

Overdominant model, n (%)

 G/G + C/C

259 (76.4)

212 (78.5)

Reference

 G/C

80 (23.6)

58 (21.5)

0.95 [0.63–1.42]

0.79

Alleles frequencies ± SD

 G

0.85 ± 0.01

0.86 ± 0.02

Reference

–

 C

0.15 ± 0.01

0.14 ± 0.02

0.92 [0.66–1.27]

0.60

rs1800797

 G/G

255 (75.2)

203 (75.2)

Reference

–

 A/G

75 (22.1)

59 (21.8)

1.09 [0.73–1.64]

0.86

 A/A

9 (2.7)

8 (3.0)

0.84 [0.31–2.31]

Recessive model, n (%)

 A/G + G/G

330 (97.3)

262 (97.0)

Reference

–

 A/A

9 (2.7)

8 (3.0)

0.83 [0.30–2.26]

0.71

Dominant model, n (%)

 G/G

255 (75.2)

203 (75.2)

Reference

–

 A/A + A/G

84 (24.8)

67 (24.8)

1.06 [0.72–1.56]

0.78

Overdominant model, n (%)

 G/G + A/A

264 (77.9)

211 (78.2)

Reference

 A/G

75 (22.1)

59 (21.8)

1.10 [0.73–1.64]

0.66

Alleles frequencies ± SD

 G

0.86 ± 0.01

0.86 ± 0.02

Reference

–

 A

0.14 ± 0.01

0.14 ± 0.02

1.02 [0.73–1.41]

0.93