Table 2 Pathways of major enrichment of 103 critical genes (p < 0.05)
Pathway ID | Pathway description | DEGs | p-value |
|---|---|---|---|
ko05031 | Amphetamine addiction | Grin2a, Ppp1r1b, Grin2c, Gria3, Grin2d | 4.93988E-05 |
ko05033 | Nicotine addiction | Grin2a, Grin2c, Gria3, Grin2d | 6.67289E-05 |
ko05030 | Cocaine addiction | Grin2a, Ppp1r1b, Grin2c, Grin2d | 0.000197593 |
ko04713 | Circadian entrainment | Grin2a, Cacna1g, Grin2c, Gria3, Grin2d | 0.00025181 |
ko05322 | Systemic lupus erythematosus | Grin2a, LOC102548682, LOC684762, C1qb, C1qc | 0.000411452 |
ko05034 | Alcoholism | Grin2a, Ppp1r1b, Grin2c, LOC102548682, LOC684762, Grin2d | 0.000447412 |
ko04610 | Complement and coagulation cascades | Cfh; RGD1564614, Clu, C1qb, C1qc | 0.000750526 |
ko04024 | cAMP signaling pathway | Grin2a, Ppp1r1b, Sox9, Grin2c, Gria3, Grin2d | 0.001188997 |
ko05150 | Staphylococcus aureus infection | Cfh; RGD1564614, C1qb, C1qc | 0.002545926 |
ko04724 | Glutamatergic synapse | Grin2a, Grin2c, Gria3, Grin2d | 0.004402465 |
ko04020 | Calcium signaling pathway | Grin2a, Cacna1g, Grin2c, Grin2d, Erbb3 | 0.004833714 |
ko05014 | Amyotrophic lateral sclerosis | Grin2a, Grin2c, Grin2d | 0.004872645 |
ko04720 | Long-term potentiation | Grin2a, Grin2c, Grin2d | 0.007170311 |
ko04728 | Dopaminergic synapse | Grin2a, Ppp1r1b, Gria3.Kif5a | 0.007913662 |
ko04392 | Hippo signaling pathway - multiple species | Ajuba, LOC100909434 | 0.01187967 |
ko05020 | Prion disease | C1qb, C1qc | 0.016656696 |
ko05202 | Transcriptional misregulation in cancer | Etv4, Gria3, LOC102548682, LOC684762 | 0.023364893 |