Fig. 3

Construction of diagnostic model for predicting CRC metastasis. A Circos graph for univariate Cox regression analysis, which represents the correlation of DMCs β value and prognosis of CRC (red: up-regulated methylation CpG Site, grey: down-regulated methylation CpG Site, purple: risk factor; green: favorable factor) in the TCGA-COAD (p-values for Cox test: 1e- 04 to 1). B Line plot of 10-fold cross-validation of the SVM-RFE algorithm for feature selection. ROC curves of diagnostic model in the TCGA cohort (C) and GEO cohort (D)