Fig. 8

Construction and validation of a risk prognostic model based on differential microRNAs targeting ZEB1 or ZEB2 in testing, training, and entire sets. A, Univariate Cox regression analysis was performed for all differential microRNAs targeting ZEB1 or ZEB2. A value of P < 0.05 was considerated statistically signifcant. B, LASSO regression of the 8 OS-related microRNAs. C, Cross-validation for tuning the parameter selection in the LASSO regression. D, Multivariate Cox regression analysis was performed on the genes derived from the LASSO regression analysis. E-G, The distribution of overall survival risk scores, survival status, heatmaps of microRNA expression (E), Kaplan-Meier curves for survival status and survival time in the training, validation, and overall groups(F), time-dependent ROC curves are used to show whether microRNA signatures are predictive of 1-, 3-, and 5-year overall survival (OS) in the training, validation, and overall groups(G)