Fig. 4

Explore the interaction genes and proteins of ZEBs, and GSEA analysis of ZEBs. A, Using GeneMania explored the gene-gene interaction network of ZEB1 and ZEB2. B, Using STRING constructed the protein-protein interaction (PPI) network of ZEB1 and ZEB2. C, the overlap of top 20 genes and proteins separately predicted by GeneMania and STRING database. D, A circos diagram revealed the wnt- pathway associated genes relation with ZEB1 and ZEB2 in KIRC. E, Reactome pathway analysis of ZEB1 using GSEA. F, Reactome pathway analysis of ZEB2 using GSEA