Fig. 1

Article flowchart. The expression of ZEB1 and ZEB2 in KIRC is correlated with unfavorable prognosis. The flow chart comprehensively illustrates the various analyses conducted in this study. It is observed that microRNAs (hsa-miR-130b-3p and hsa-miR-138-5p) play a regulatory role in modulating the expression of ZEB1 and ZEB2. The upregulation of ZEB1 and ZEB2 mRNA in KIRC significantly affects anoikis, immune cell infiltration, and patient survival. These findings offer valuable insights into the molecular mechanisms and clinical relevance of ZEB1 and ZEB2 in the context of KIRC