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Table 1 Hub genes with high node degrees from protein–protein interaction networks

From: Integrated bioinformatics analysis for exploring potential biomarkers related to Parkinson’s disease progression

Node

Node degree

Regulation

ESR1

16

Up

DCN

9

Up

ELN

8

Up

ISL1

8

Up

COMP

7

Up

FMOD

7

Up

LUM

7

Up

OTX2

7

Up

CILP

6

Up

KRT14

6

Up

LAMB1

6

Up

DRD2

11

Down

SLC18A2

10

Down

DDC

9

Down

SLC6A3

9

Down

KCNJ6

8

Down

TH

8

Down

PITX3

7

Down

MT-CO2

5

Down

MT-CYB

5

Down

SLC18A1

5

Down