Fig. 6
From: Network-based identification of critical regulators as putative drivers of human cleft lip
miRNAs might act as the CL regulators through Wnt pathway. (a) Subnetwork 1. (b) Subnetwork 2. (c) Schematic model of hsa-mir-27b regulation in Wnt pathway. An upregulated hsa-mir-27b suppresses SMAD1 expression, which accordingly leads to an upregulation of WNT3A due to low level of SMAD1. ↑ represents up-regulation and ↓ represents down-regulation