Fig. 2

Identification of dynamic gene markers in AF samples. Genes with gestational time dependent increasing (a) or decreasing (c) trends were identified. Functional classification of these two classes of genes revealed distinctive enriched biological processes, pathways, mouse phenotypes and transcription factor binding sites (TFBS) associated these two groups of genes.Enriched functional classifications corresponding to genes that increase throughout gestation were displayed in panel (b), and enriched functional classifications corresponding to genes that decrease throughout gestation were displayed in panel (d). Gene set functional enrichment analysis was performed using Toppgene suite (https://toppgene.cchmc.org/)