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Figure 3 | BMC Medical Genomics

Figure 3

From: The removal of multiplicative, systematic bias allows integration of breast cancer gene expression datasets – improving meta-analysis and prediction of prognosis

Figure 3

Dataset-specific bias in published Affymetrix breast cancer studies. Multidimensional scaling for all common probesets (22,215) for 1107 breast tumours from six published studies [16–21] on U133A, U133AA and U133 plus 2.0 GeneChips. Tumours from different datasets are distinguished by symbol. Tumours assigned to one of the five Sorlie et al. subtypes by centroid prediction are discriminated by colours. With uncorrected data the tumours cluster by study, following mean-centering the tumours cluster by molecular subtype.

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BMC Medical Genomics

ISSN: 1755-8794

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